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The Principle Of Extracts From Senna Leaf

Baoji Herbest Bio-Tech Co.,Ltd | Updated: Mar 30, 2020

The main active ingredient of senna leaf is senna glycosides. After oral senna, senna glucoside most arrived in e. without intestinal absorption, degradation by different metabolic pathways of senna's more rhein anthracene ketone, it can be excited M - receptor on the intestinal smooth muscle, increase the intestinal peristalsis, and also can inhibit intestinal membrane sodium, potassium - atpase, hinder the na, make the intestinal higher osmotic pressure, keep a large number of moisture, promote intestinal peristalsis and defecation.

senna leaf extracts

After partial anthracycline is absorbed from the small intestine, it is converted into aglycone by the liver, and then stimulated the pelvic nerve plexus to increase intestinal peristalsis. On the first day of the study, the experimental group developed diarrhea symptoms of different degrees, and the severity was proportional to the dose given. The diarrhea reached a peak after the second day, and then gradually recovered. However, the amount of drinking water in the mice on the first day did not increase with the severity of diarrhea. Severe diarrhea resulted in the loss of a large amount of water electrolytes, intestinal tube expansion, which affected the return of intestinal wall veins, and the leakage of plasma into the intestinal tube. Meanwhile, the water could not be replenished in time, resulting in the decrease of blood volume and the shock of low blood volume.


众购彩票登陆Pathological examination showed that all the intestinal mucosal epithelium was necrotic, which was related to the increased peristalsis of the intestine and the expansion of the intestinal wall during diarrhea. However, there was no significant change in the detection of the electrolyte level of the surviving mice, which may be because the surviving mice in each group had returned to the normal state at the end of the experiment, and the water electrolyte level tended to be stable.


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